2016 - Volume 3 - Issue 1 Articles
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Review Article | ArticleApril 14, 2016 | Pages : 205 - 450Abstract CRISPR is a popular approach for genome engineering, as it requires very few components (Cas9 and a gRNA) and can be adapted to knockdown, knockout or activate expression of specific genes in a wide variety of organisms. Although CRISPR is certainly .....
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Research Article | ArticleApril 26, 2016 | Pages : 205 - 450Abstract We recently described RNA editing in two sites of the Grin1b gene transcript of Danio rerio embryos. Upon further investigation, we discovered the editing of one of these sites changes with age (embryo vs. adult), as well as differing between male an.....
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Research Article | ArticleApril 26, 2016 | Pages : 205 - 450Abstract Enzymatic DNA methylation is an important constituent of the cell epigenetic regulatory system. It is tissue (cell) and age specific and involved in regulation of all genetic functions including transcription, DNA replication and repair, gene transpo.....
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Research Article | ArticleMay 16, 2016 | Pages : 205 - 450Abstract Research efforts have focused on discovering key biochemical pathways of tumorigenesis and identifying genes that are central to the development of brain cancer. PTEN, a tumor suppressor in the PI3K/AKT pathway is frequently deleted in glioblastoma. .....
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Research Article | ArticleBy Annette Uwineza Janvier Hitayezu Janvier Ndinkabandi Leon Mutesa Seraphine Murorunkwere Védaste NdahindwaJune 02, 2016 | Pages : 205 - 450Abstract Background: Down syndrome is the most common chromosome abnormality recognized to cause intellectual disability in all human ethnic groups worldwide. Advanced maternal age has been identified as risk factor associated with underlying mechanism of chr.....